Trials · Topics · Palliative / Bone Metastases
Palliative / Bone Metastases clinical trials
20 Palliative / Bone Metastases trials (Radiation Oncology) summarized for fellows and board review, newest first within each disease. Each summary covers design, results, toxicity and what changed in practice.
Jump to: SBRT/SABR · Spine SBRT · Brain Metastases RT · Bone Metastases RT · Palliative Care · Spine RT · Thoracic RT
SBRT/SABR (5)
- ESTRO-EORTC Oligometastatic Consensus Lancet Oncol 2020Standardized definition and classification of OMD is essential for trial design consistency. The ≤5 metastases threshold in ≤3 organs is supported by biologic and...
- ORIOLE JAMA Oncol 2020SBRT to all visible oligometastatic lesions significantly reduced progression at 6 months and improved PFS in recurrent hormone-sensitive prostate cancer. The PSMA...
- Oligometastatic NSCLC LCT JCO 2019LCT significantly improved both PFS and OS in oligometastatic NSCLC patients with controlled disease after first-line systemic therapy, representing the strongest...
- SABR-COMET Lancet 2019SABR was associated with a clinically meaningful but non-statistically-significant improvement in OS (HR 0.57) in this underpowered phase II trial. PFS was...
- STOMP JCO 2018MDT with SBRT or surgery to oligometastatic prostate cancer lesions showed a trend toward prolonging ADT-free survival (8-month delay) without reaching statistical...
Spine SBRT (4)
- RTOG 0631 JAMA Oncol 2023SBRT achieved significantly superior local control compared to conventional single-fraction RT for spinal metastases but did not significantly improve pain response...
- ISRC Spinal SBRT Guidelines IJROBP 2012ISRC consensus guidelines provide standardized target volume delineation and dose constraints for spinal SBRT that have been widely adopted across institutions....
- Spine SBRT Pain Outcomes Lancet Oncol 2012Spine SBRT (27-30 Gy in 3-5 fractions) provides excellent pain relief and local control for spinal metastases. Vertebral compression fracture is the predominant late...
- Spinal Cord Radiosurgery Cancer 2010Single-fraction spinal radiosurgery achieves excellent neurologic preservation and local control for ESCC with acceptable toxicity and no radiation myelopathy when...
Brain Metastases RT (3)
- SRS Radiation Necrosis Predictors IJROBP 2017V12 Gy is the strongest predictor of radiation necrosis after SRS for brain metastases, with V12 >10.5 cm³ associated with 10-fold increased risk. Limiting V12 and...
- WBRT Prognostic Score JCO 2016A new prognostic score combining KPS, extracranial mets, brain met number, primary tumor type, and age accurately identifies brain metastasis patients with favorable...
- SRS vs WBRT for Brain Metastases JAMA 2006Adding WBRT to SRS did not improve OS compared to SRS alone for ≤3 brain metastases despite significantly better intracranial control. WBRT caused significant...
Bone Metastases RT (2)
- ASTRO Bone Metastases Guidelines Pract Radiat Oncol 2017Multiple dose/fractionation schedules are effective for bone pain palliation. Single-fraction 8 Gy is recommended as the standard for uncomplicated bone metastases...
- RTOG 97-14 JNCI 2005Single-fraction 8 Gy achieves equivalent pain palliation to 30 Gy/10 fractions for bone metastases from breast and prostate cancer with less acute toxicity. The...
Palliative Care (2)
- EOL Palliative RT Trends JAMA Oncol 2019The rate of EOL palliative RT in the United States has declined over time with increasing use of single-fraction RT. This trend suggests improving alignment with...
- Early Palliative Care RCT NEJM 2010Early palliative care integration from diagnosis improved QoL, reduced depressive symptoms, and was associated with longer survival in metastatic NSCLC compared to...
Spine RT (2)
- SINS Spine 2014The SINS has excellent inter-rater reliability across spine surgeons and radiation oncologists, making it a practical tool for standardizing spinal instability...
- Patchell ESCC Surgery Trial Lancet 2005Direct decompressive surgery followed by RT significantly improved walking ability, duration of ambulation, bladder/bowel function, and OS compared to RT alone for...
Thoracic RT (2)
- ASTRO Thoracic Palliative RT Guidelines Pract Radiat Oncol 2011Short-course hypofractionated RT (17 Gy/2 or 20 Gy/5) is effective for palliation of thoracic symptoms from lung cancer. Longer-course RT (30-39 Gy/10-13) offers...
- QUAD SHOT Radiother Oncol 2005The QUAD SHOT regimen (3.5 Gy × 4 fractions over 2 days) achieves meaningful symptom palliation in poor-PS advanced NSCLC patients with acceptable toxicity and allows...