Other clinical trials
20 Other trials (Classical Hematology) summarized for fellows and board review, newest first within each disease. Each summary covers design, results, toxicity and what changed in practice.
Jump to: Transfusion · Pregnancy · Eosinophilia · HLH · TMA · Chronic Granulomatous Disease · ESA safety · Porphyria · Severe Chronic Neutropenia
Transfusion (7)
- CHIPS trial JAMA 2026In actively bleeding cardiac surgery patients on cardiopulmonary bypass, cold-stored platelets held for up to 21 days were noninferior to standard room-temperature...
- TRICS-III NEJM 2017A restrictive RBC transfusion strategy was noninferior to a liberal strategy in high-risk cardiac surgery patients, confirming that Hgb <7.5 g/dL is a safe...
- WOMAN 2017TXA significantly reduced death from PPH but did not reduce hysterectomy, meeting only part of the composite primary endpoint. The mortality reduction was driven by...
- PROPPR JAMA 2015The 1:1:1 ratio did not significantly improve 24-hour or 30-day survival compared to 1:1:2, but significantly improved hemostasis and reduced early hemorrhagic death...
- TRISS NEJM 2014A restrictive RBC transfusion strategy (Hgb trigger 7 g/dL) was noninferior to a liberal strategy (trigger 9 g/dL) in adults with septic shock, confirming the safety...
- CRASH-2 Lancet 2010Tranexamic acid given within 8 hours of injury significantly reduced all-cause and hemorrhage-related mortality in adult trauma patients, with no increase in...
- TRICC NEJM 1999A restrictive RBC transfusion strategy (trigger Hgb <7 g/dL) was at least as safe as and likely superior to a liberal strategy in most critically ill patients...
Pregnancy (3)
- ALIFE2 Lancet 2023Adding LMWH to low-dose aspirin did not improve live birth rates in women with unexplained recurrent miscarriage, providing definitive evidence against routine LMWH...
- ASPRE NEJM 2017Low-dose aspirin 150 mg/day started at 11-14 weeks significantly reduced the incidence of preterm preeclampsia by 62% in high-risk women identified by first-trimester...
- ALIFE NEJM 2010Neither LMWH plus aspirin nor aspirin alone improved live birth rates compared to placebo in women with inherited thrombophilia and recurrent miscarriage, refuting...
Eosinophilia (2)
- NATRON trial (benralizumab) Nat Med 2026Add-on benralizumab significantly reduced HES flares vs placebo with placebo-like tolerability. Establishes IL-5Rα blockade as an effective steroid-sparing strategy...
- Mepolizumab-HES NEJM 2008Mepolizumab significantly reduced peripheral eosinophil counts and enabled major steroid dose reduction in patients with HES, establishing anti-IL-5 therapy as...
HLH (2)
- Emapalumab-HLH NEJM 2020Emapalumab achieved meaningful responses (ORR 63%) in children with primary HLH refractory to conventional therapy, enabling most to proceed to HSCT - the first...
- HLH-2004 Blood 2017HLH-2004 induction/continuation achieved hematologic response in ~64% with 5-yr survival of 66% in transplanted patients, establishing the protocol as the global...
TMA (2)
- ALXN1210-aHUS-311 (Ravulizumab aHUS) Kidney Int 2020Ravulizumab provides complete, sustained C5 inhibition and achieves complete TMA response in 53.6% of complement-inhibitor-naive adults with aHUS, comparable to...
- Eculizumab aHUS (C08-002/003) NEJM 2013Eculizumab inhibited complement-mediated TMA with significant platelet recovery, TMA event-free status, and time-dependent renal improvement in aHUS, establishing...
Chronic Granulomatous Disease (1)
- IFN-gamma CGD 1991Interferon-gamma 50 μg/m² SC three times weekly significantly reduced the frequency, number, and duration of serious infections in patients with CGD, regardless of...
ESA safety (1)
- TREAT NEJM 2009Targeting Hb ~13 g/dL with darbepoetin in T2DM+CKD patients did not reduce the risk of CV or renal endpoints and was associated with a 92% relative increase in stroke...
Porphyria (1)
- ENVISION NEJM 2020Givosiran reduced acute hepatic porphyria attacks by 74% versus placebo, with rapid and sustained reduction in ALA/PBG accumulation, establishing RNAi-targeted ALAS1...
Severe Chronic Neutropenia (1)
- Dale 1993 (G-CSF SCN) Blood 1993Filgrastim effectively raised ANC and reduced infection-related events in patients with severe chronic neutropenia, regardless of etiology (idiopathic, cyclic, or...