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Thymic Epithelial Tumors — Treatment
First-line
Second-line
SECOND-LINE
Thymic epithelial
tumor
thymoma / carcinoma
Resectable (stage I–II)
Locally advanced (III–IVA)
Advanced / metastatic (IVB)
Refractory thymic carcinoma
Surgery
Complete resection (R0)
+ adjuvant RT if stage II–III / margin+
Multimodal
Neoadjuvant CAP → resection → RT
cisplatin/doxorubicin/cyclophosphamide
First-line
CAP chemotherapy
cisplatin-based
Antiangiogenic
Lenvatinib
REMORA ↗
Other
Octreotide / everolimus
thymoma-preferred (non-IO)