Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Small Cell Lung Cancer — First-Line & Relapse

First-line Second-line Later-line SECOND-LINE THIRD-LINE / LATER Small cell lung cancer by stage → systemic Rx Extensive-stage Limited-stage Relapse · PS 0–2 Relapse · PS 3–4 Standard Chemo + atezolizumab → lurbi/atezo maint IMpower133 / IMforte ↗ Alternative Chemo + durvalumab CASPIAN ↗ Definitive Cis/etoposide + RT → durvalumab ADRIATIC ↗ DLL3 Tarlatamab DeLLphi-301 ↗ If naïve Lurbinectedin PM1183 ↗ Cytotoxic Topotecan PO or IV ↗ Supportive Best supportive care ± palliative RT symptom-directed