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Resectable / Early-Stage NSCLC — Perioperative Therapy
Resectable / early-stage
NSCLC
by stage & driver
Resectable IB–IIIA · neoadjuvant
Resected · adjuvant (driver–)
Resected · EGFR-mutant
Resected · ALK+
Unresectable stage III
Neoadjuvant
Chemo + nivolumab
CheckMate 816 ↗
Perioperative
Chemo + pembrolizumab
KEYNOTE-671 ↗
PD-L1 ≥ 1%
Adjuvant atezolizumab
IMpower010 ↗
Alternative
Adjuvant pembrolizumab
KEYNOTE-091 ↗
Adjuvant
Osimertinib
ADAURA ↗
CNS
Adjuvant
Alectinib
ALINA ↗
CNS
After chemoRT
Consolidation durvalumab
PACIFIC ↗