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Advanced Thyroid Cancer — Systemic Therapy
Advanced thyroid
cancer by type
DTC · RAI-refractory
Medullary (MTC)
Anaplastic (ATC)
VEGFR TKI
Lenvatinib
SELECT ↗
VEGFR TKI
Sorafenib
DECISION ↗
RET/NTRK
Selpercatinib
LIBRETTO-001 ↗
BRAF
Dabrafenib + trametinib
ROAR ↗
RET
Selpercatinib / pralsetinib
LIBRETTO ↗
RET-independent
Cabozantinib / vandetanib
EXAM / ZETA ↗
BRAF
Dabrafenib + trametinib
BRAF V600E ↗
Other
Chemoradiation / clinical trial
aggressive