Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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MGUS — Risk Stratification & Monitoring

MGUS M-protein < 3 g/dL < 10% plasma cells Low-risk MGUS Intermediate / high-risk IgM MGUS Monitor Recheck SPEP at 6 mo, then q2–3 yr no marrow / imaging needed Work-up Bone marrow + whole-body imaging then annual follow-up Monitor Surveillance for Waldenström / lymphoma distinct biology