Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Immune-Related Adverse Event (irAE) Management

Immune-related adverse event on checkpoint inhibitor Grade 1 Grade 2 Grade 3 Grade 4 Special cases Mild Continue ICI + monitor supportive care Moderate Hold ICI; prednisone 0.5–1 mg/kg resume when ≤ grade 1 Severe Hold/d-c ICI; methylpred 1–2 mg/kg if no improvement 48–72h → infliximab / MMF Life-threatening Permanently discontinue ICI IV methylpred 1–2 mg/kg + specialist Myocarditis High-dose steroids + permanent d-c medical emergency Endocrine Hormone replacement may continue ICI