Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Multiple Myeloma — Treatment

First-line Second-line SECOND-LINE Multiple myeloma (newly diagnosed) Transplant-eligible Transplant-ineligible Relapsed / refractory Quadruplet Dara-VRd → autologous SCT PERSEUS ↗ Maintenance Lenalidomide maintenance post-transplant ↗ Triplet Dara-Rd MAIA ↗ Triplet VRd SWOG S0777 ↗ Triplet Triplet by prior exposure POLLUX / CASTOR ↗ BCMA CAR-T Cilta-cel / ide-cel CARTITUDE-4 ↗ BiTE Teclistamab / talquetamab bispecific ↗