Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Myeloproliferative Neoplasms — Treatment

Myeloproliferative neoplasms (MPN) Polycythemia vera Essential thrombocythemia Myelofibrosis All patients Phlebotomy + low-dose aspirin Hct < 45% High-risk Hydroxyurea or ropeginterferon cytoreduction ↗ Refractory Ruxolitinib RESPONSE ↗ Low-risk Low-dose aspirin observation High-risk Hydroxyurea cytoreduction JAKi Ruxolitinib / fedratinib COMFORT ↗ Thrombocytopenic Pacritinib PERSIST-2 ↗ Anemic Momelotinib MOMENTUM ↗ Curative Allogeneic transplant only curative option