Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Myelodysplastic Syndromes — Treatment by Risk

Myelodysplastic syndromes (MDS) Lower-risk (IPSS-R low/int) Higher-risk (IPSS-R high/very-high) Anemia, low EPO Erythropoiesis-stimulating agent symptomatic anemia ↗ Ring sideroblasts Luspatercept COMMANDS ↗ del(5q) Lenalidomide del(5q) ↗ Disease-modifying Hypomethylating agent AZA-001 ↗ Curative Allogeneic transplant only curative option