Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Mantle Cell Lymphoma — Treatment

First-line Second-line SECOND-LINE Mantle cell lymphoma Young / fit Older / less fit Relapsed / refractory Intensive Cytarabine induction → ASCT + R-maint LYMA ↗ BTKi-added Add ibrutinib to induction TRIANGLE ↗ Standard Bendamustine + rituximab → R-maint StiL ↗ BTKi-added BR + ibrutinib SHINE ↗ BTKi Covalent BTKi / pirtobrutinib BRUIN ↗ Cellular Brexucabtagene autoleucel ZUMA-2 ↗