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Mantle Cell Lymphoma — Treatment
First-line
Second-line
SECOND-LINE
Mantle cell
lymphoma
Young / fit
Older / less fit
Relapsed / refractory
Intensive
Cytarabine induction → ASCT + R-maint
LYMA ↗
BTKi-added
Add ibrutinib to induction
TRIANGLE ↗
Standard
Bendamustine + rituximab → R-maint
StiL ↗
BTKi-added
BR + ibrutinib
SHINE ↗
BTKi
Covalent BTKi / pirtobrutinib
BRUIN ↗
Cellular
Brexucabtagene autoleucel
ZUMA-2 ↗