Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Follicular Lymphoma — Treatment

First-line Second-line SECOND-LINE Follicular lymphoma (grade 1–3a) Low burden / asymptomatic High burden (GELF) Relapsed / refractory Watch Observation watchful waiting If desired Rituximab monotherapy RESORT ↗ Chemo+R Bendamustine + rituximab → R-maint StiL ↗ Chemo+O Obinutuzumab + chemo GALLIUM ↗ Combo Lenalidomide + rituximab AUGMENT ↗ Cellular CD19 CAR-T ZUMA-5 ↗ BiTE Mosunetuzumab bispecific ↗ EZH2 Tazemetostat EZH2-mutant ↗