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Follicular Lymphoma — Treatment
First-line
Second-line
SECOND-LINE
Follicular lymphoma
(grade 1–3a)
Low burden / asymptomatic
High burden (GELF)
Relapsed / refractory
Watch
Observation
watchful waiting
If desired
Rituximab monotherapy
RESORT ↗
Chemo+R
Bendamustine + rituximab → R-maint
StiL ↗
Chemo+O
Obinutuzumab + chemo
GALLIUM ↗
Combo
Lenalidomide + rituximab
AUGMENT ↗
Cellular
CD19 CAR-T
ZUMA-5 ↗
BiTE
Mosunetuzumab
bispecific ↗
EZH2
Tazemetostat
EZH2-mutant ↗