Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Diffuse Large B-Cell Lymphoma — Treatment

First-line Second-line Later-line SECOND-LINE THIRD-LINE / LATER Diffuse large B-cell lymphoma (DLBCL) Frontline Relapsed · transplant-eligible Relapsed · later lines Standard R-CHOP ×6 GELA LNH98-5 ↗ Improved PFS Pola-R-CHP POLARIX ↗ Early relapse CD19 CAR-T ZUMA-7 ↗ Late relapse Salvage chemo → autologous SCT CORAL ↗ Combo Tafasitamab + lenalidomide L-MIND ↗ BiTE Glofitamab / epcoritamab bispecific ↗ ADC Loncastuximab tesirine LOTIS-2 ↗