Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Primary CNS Lymphoma — Treatment

First-line Second-line SECOND-LINE Primary CNS lymphoma (immunocompetent) Induction Consolidation Relapsed / refractory HD-MTX backbone MATRix (HD-MTX + cytarabine + thiotepa + rituximab) MATRix ↗ Preferred (fit) Thiotepa-based autologous HSCT durable ↗ Alternative Whole-brain RT neurotoxicity risk Targeted Ibrutinib / lenalidomide or re-induction HD-MTX