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Chronic Lymphocytic Leukemia — Treatment
First-line
Second-line
SECOND-LINE
CLL needing
treatment
Frontline · del(17p)/TP53
Frontline · no del(17p)
Relapsed / refractory
Continuous
Covalent BTK inhibitor
ELEVATE-TN ↗
Fixed-duration
Venetoclax + obinutuzumab
CLL14 ↗
Continuous
BTK inhibitor
ELEVATE-TN ↗
Fixed-duration
Venetoclax + obinutuzumab
CLL14 ↗
Fixed-duration
Venetoclax + rituximab
MURANO ↗
Switch class
Pirtobrutinib
BRUIN ↗
Cellular
CD19 CAR-T (liso-cel)
TRANSCEND CLL ↗