Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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GEP Neuroendocrine Tumors — Systemic Therapy

First-line Second-line SECOND-LINE GEP neuroendocrine neoplasm Well-diff NET · SSTR+ Poorly-diff NEC Progressive after SSA Antiproliferative Somatostatin analog CLARINET ↗ PRRT 177Lu-DOTATATE NETTER-1 ↗ Small-cell-like Platinum + etoposide high-grade NEC mTOR Everolimus RADIANT-4 ↗ TKI (pNET) Sunitinib pancreatic NET ↗ Chemo (pNET) Capecitabine + temozolomide CAPTEM ↗