Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Esophageal / GEJ Cancer — Treatment by Histology

Esophageal / GEJ cancer Localized, resectable Neoadjuvant chemoRT → surgery CROSS Adjuvant nivolumab if residual disease CheckMate-577 ↗ Perioperative chemo (adeno) — FLOT FLOT4 Advanced — adenocarcinoma Nivolumab + chemo PD-L1 CPS ≥5 — CheckMate-649 ↗ Trastuzumab + chemo + pembrolizumab HER2+ — KEYNOTE-811 ↗ Chemo doublet biomarker-negative Advanced — squamous cell carcinoma Pembrolizumab + chemo KEYNOTE-590 ↗ Nivolumab + chemo, or nivolumab + ipilimumab CheckMate-648 ↗