Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Advanced Biliary Tract Cancer — Systemic Therapy

First-line Second-line SECOND-LINE Advanced biliary tract cancer First-line chemo + IO Molecularly targeted Second-line chemo Standard Gem/cisplatin + durvalumab TOPAZ-1 ↗ Alternative Gem/cisplatin + pembrolizumab KEYNOTE-966 ↗ FGFR2 Pemigatinib / futibatinib FGFR2 fusion ↗ IDH1 Ivosidenib ClarIDHy ↗ HER2 Trastuzumab / T-DXd HER2-amplified ↗ BRAF Dabrafenib + trametinib ROAR ↗ Cytotoxic FOLFOX ABC-06 ↗ Always Clinical trial genotype-directed