Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Aplastic Anemia — Treatment

First-line Second-line SECOND-LINE Severe aplastic anemia (acquired) Young + matched donor Older / no donor Relapsed / refractory Curative Allogeneic HSCT first-line if young, matched sibling IST ATG + cyclosporine + eltrombopag triple immunosuppression ↗ Salvage Alternative-donor HSCT / repeat IST individualized