Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

← All algorithms  ·  Related notes →

Early-stage HER2+ Breast Cancer

Early stage HER2+ < 2 cm and node negative Surgery pT1 pN0 Weekly paclitaxel + trastuzumab × 12 Tolaney, NEJM 2015 Complete 1 year of trastuzumab pT2 or pN1+ Adjuvant chemo + trastuzumab ± pertuzumab APHINITY ↗ ≥ 2 cm or node positive Neoadjuvant chemo + trastuzumab + pertuzumab NeoSphere / APHINITY ↗ Surgery pCR Complete 1 yr trastuzumab ± pertuzumab APHINITY ↗ Consider neratinib × 1 year ExteNET (HR+ / N+) ↗ Residual disease T-DM1 × 14 (complete 1 year) KATHERINE ↗ Consider neratinib × 1 year ExteNET (HR+ / N+) ↗