Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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HER2+ Advanced Breast Cancer — Systemic Therapy

First-line Second-line Later-line SECOND-LINE THIRD-LINE / LATER HER2+ advanced breast cancer First-line Second-line Third-line + Preferred THP → maintenance HP CLEOPATRA ↗ ADC Trastuzumab deruxtecan DESTINY-Breast03 ↗ CNS CNS-active Tucatinib + trastuzumab + cape HER2CLIMB ↗ CNS ADC T-DM1 EMILIA ↗ Oral TKI Neratinib / lapatinib + cape NALA ↗ Fc-engineered Margetuximab + chemo SOPHIA ↗