Study aid only. Verify against current guidelines, primary literature, staging manuals, and prescribing information before clinical use.

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Primary Bone Sarcoma — Treatment by Histology

First-line Second-line SECOND-LINE Primary bone sarcoma by histology Osteosarcoma (localized) Ewing sarcoma (localized) Chondrosarcoma Metastatic / relapsed Curative Neoadjuvant MAP → resection → adjuvant MAP high-dose MTX/doxorubicin/cisplatin Curative VDC/IE (interval-compressed) → local control + maintenance per protocol Surgery Wide surgical resection chemo/RT generally ineffective Antiangiogenic Regorafenib REGOBONE ↗ Ewing Irinotecan + temozolomide or high-dose ifosfamide